Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Terodiline is a Ca 2+ blocker and M1-selective muscarinic receptor (mAChR) antagonist with Kb of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline has potential to the treatment of urinary frequency and urge incontinence [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | Terodiline is a Ca 2+ blocker and M1-selective muscarinic receptor (mAChR) antagonist with Kb of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline has potential to the treatment of urinary frequency and urge incontinence [1]. |
In vivo | Terodiline (80 mg/kg; S.C.) displays equivalent efficacy in reducing intravesical bladder pressure and carbachol-induced salivary secretion, with an ID 50 of 24 and 35 mg/kg, respectively. Additionally, it is effective in dilating pupils, showing an ED 50 of 59 mg/kg. This research utilized both male and female Hartley guinea pigs weighing between 200-600 g. The terodiline dosage administered subcutaneously was 80 mg/kg, resulting in an observed ID 50 of 24±6 mg/kg. It was noted that administering higher doses proved to be lethal. |
Molecular Weight | 281.44 |
Formula | C20H27N |
CAS No. | 15793-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Terodiline 15793-40-5 inhibitor inhibit