Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
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Description | TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM). |
Targets&IC50 | MMP:20 μM, MMP:1.5 nM (Ki) |
In vitro | TAPI-2 bounds to h-meprin with IC50 20 μM for h-meprin β subunit and 1.5 nM for h-meprin α subunit. Generally, h-meprin α is inhibited more strongly than the β subunit [1]. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5–40 μM) [2]. |
Synonyms | TAPI-2 |
Molecular Weight | 415.53 |
Formula | C19H37N5O5 |
CAS No. | 187034-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (48.13 mM)
You can also refer to dose conversion for different animals. More
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TNF Protease Inhibitor 2 187034-31-7 Proteases/Proteasome MMP TAPI 2 TAPI-2 TAPI2 inhibitor inhibit