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TASP 0277308

Catalog No. T41145 CAS 945725-50-8

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia.

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TASP 0277308, CAS 945725-50-8

Pack Size	Availability	Price/USD	Quantity
5 mg	35 days	$ 793.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	539.48
Formula	C23H28Cl2N6O3S
CAS No.	945725-50-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fujii et al (2012) Amelioration of collagen-induced arthritis by a novel S1P 1 antagonist with immunomodulatory activities. J.Immunol. 188 PMID: 22131329 2. Fujii et al (2012) Blocking S1P interaction with S1P 1 receptor by a novel competitive S1P 1 -selective antagonist inhibits angiogenesis. Biochem.Biophys.Res.Commun. 419 754 PMID: 22387544

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TASP 0277308 945725-50-8 TASP-0277308 TASP0277308 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.