Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 108.00 | |
25 mg | In stock | $ 215.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
200 mg | In stock | $ 843.00 |
Description | T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC). |
Targets&IC50 | TMEM16A (Cl- channel):1 µM |
In vitro | T16Ainh-A01 (0.3-30μM) can significantly reduce the inward and outward components of IClCa and inhibit IClCa in RUICC without significantly affecting L-type Ca2+ current[1]. T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism[2]. |
Molecular Weight | 416.52 |
Formula | C19H20N4O3S2 |
CAS No. | 552309-42-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMF: 10 mg/mL (24.01 mM)
DMSO: 4 mg/mL(9.6 mM)
You can also refer to dose conversion for different animals. More
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T16Ainh-A01 552309-42-9 Membrane transporter/Ion channel Chloride channel inhibit T16AinhA01 Chloride Channel T-16Ainh-A01 T16Ainh A01 Cl-Channels Inhibitor inhibitor