Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T0467 is a chemical compound that activates the translocation of parkin to the mitochondria in a PINK1-dependent manner in vitro. However, T0467 does not induce the accumulation of PINK1 in the mitochondria of dopaminergic neurons. As a result, T0467 shows promise as a potential compound for activating the PINK1-Parkin signaling pathway and can be utilized in research related to Parkinson's disease and related disorders.
Description | T0467 is a chemical compound that activates the translocation of parkin to the mitochondria in a PINK1-dependent manner in vitro. However, T0467 does not induce the accumulation of PINK1 in the mitochondria of dopaminergic neurons. As a result, T0467 shows promise as a potential compound for activating the PINK1-Parkin signaling pathway and can be utilized in research related to Parkinson's disease and related disorders. |
In vitro | T0467 (2.5-20 μM; 3 hours) induces the mitochondrial translocation of GFP-Parkin in HeLa/GFP-Parkin cells, with significant translocation observed at concentrations exceeding 12 μM [1]. Specifically, treatment with 20 μM T0467 for 3 hours results in mitochondrial translocation of GFP-Parkin in approximately 21% of cells [1]. Furthermore, T0467 is non-toxic in Drosophila at concentrations below 50 μM. The compound, along with others studied, effectively mitigates defects in larval locomotion and mitochondrial morphology, as well as decreased ATP production, associated with PINK1 inactivation. Additionally, T0467 and KTP enhance mitochondrial Ca2+ response in Drosophila larval muscles [1]. |
Synonyms | T0467 |
Molecular Weight | 441.502 |
Formula | C24H26F3N5 |
CAS No. | 859518-94-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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T0467 859518-94-8 T 0467 T-0467 inhibitor inhibit