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T-2007

Catalog No. T28901 CAS 21914-07-8

Synonyms: 5,5-Diphenylbarbituric acid, DPB

T-2007 is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and gamma-aminobutyric acid (GABA) receptor agonist. T2007 and its analogs upregulates CYP3A4 and MDR1. T-2007 depressed both the degree and the duration of posttetanic potentiation (PTP) in a dose-dependent manner.

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T-2007, CAS 21914-07-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	5,5-Diphenylbarbituric acid, DPB
Molecular Weight	280.28
Formula	C16H12N2O3
CAS No.	21914-07-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fan J, Maeng HJ, Du Y, Kwan D, Pang KS. Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells. Eur J Pharm Sci. 2011 Jan 18;42(1-2):19-29. doi: 10.1016/j.ejps.2010.10.001. PubMed PMID: 20955791. 2. Thacker DL, Abernethy DR, Raines A, Flockhart DA. Method for the determination of 5,5-diphenylbarbituric acid and its separation from 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):149-55. PubMed PMID: 9686882. 3. Nims RW, McClain RM, Manchand PS, Belica PS, Thomas PE, Mellini DW, Utermahlen WE Jr, Lubet RA. Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat. J Pharmacol Exp Ther. 1994 Jul;270(1):348-55. PubMed PMID: 8035330. 4. Zavadil AP 3rd, Dretchen KL, Raines A. Diphenylbarbituric acid: its effects on neuromuscular and spinal cord function in the cat. Epilepsia. 1985 Mar-Apr;26(2):158-66. PubMed PMID: 2985376.

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

T-2007 21914-07-8 5,5-Diphenylbarbituric acid T 2007 DPB T2007 inhibitor inhibit

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