store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.
Description | Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase. |
Targets&IC50 | Lysosomal α-mannosidase:0.2 μM, Golgi α-mannosidase II:0.2 μM |
In vitro |
Swainsonine (0-40 μM ; 12 h) showed anti-proliferative activity in U251 and LN444 cells.[2] Swainsonine (30 μM ; 12 h) induced apoptosis and cell cycle arrest in G2/M phase and decreased the expression of CyclinD1 and CDK4 protein levels and increased the expression of p16 protein level.[2] Swainsonine (30 μM ; 12 h) reduces glioma cell migration and invasion.[2] |
In vivo | Swainsonine (1 mg/kg ; intraperitoneal injection ; twice daily for 10 days) and cisplatin increased the antitumor efficacy in mice.[3] |
Synonyms | Tridolgosir |
Molecular Weight | 173.21 |
Formula | C8H15NO3 |
CAS No. | 72741-87-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 9.0 mg/mL (52.0 mM ), Sonication and heating are recommended.
DMSO: 9.0 mg/mL (52.0 mM ), Sonication and heating are recommended.
H2O: 3.2 mg/mL (18.5 mM ), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Swainsonine 72741-87-8 Apoptosis Microbiology/Virology Others Antibiotic Tridolgosir inhibitor inhibit