Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor. Squarunkin A hydrochloride selectively inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10 nm. Squarunkin A hydrochloride interferes with the activation of Src kinase in cells [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor. Squarunkin A hydrochloride selectively inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10 nm. Squarunkin A hydrochloride interferes with the activation of Src kinase in cells [1]. |
In vitro | Treatment with Squarunkin A at concentrations of 2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM leads to a concentration-dependent decrease in Src phosphorylation [1]. Unlike other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which attach to S-prenylated proteins, Squarunkin A does not interact with their lipoprotein-binding sites. Instead, it targets and binds to UNC119 within cell lysates, thereby disrupting Src activation [1]. |
Molecular Weight | 560.02 |
Formula | C25H33ClF3N5O4 |
CAS No. | 2253744-55-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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Squarunkin A hydrochloride 2253744-55-5 Squarunkin A Hydrochloride inhibitor inhibit