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Sorbinicate

Catalog No. T26201 CAS 6184-06-1

Synonyms: LG10017, Sorbinicatum, LG10,017, LG-10017, LG 10017

Sorbinicate is an antihypercholesterolaemic and vasodilating nicotinic acid ester.

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Sorbinicate, CAS 6184-06-1

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Sorbinicate is an antihypercholesterolaemic and vasodilating nicotinic acid ester.

Synonyms	LG10017, Sorbinicatum, LG10,017, LG-10017, LG 10017
Molecular Weight	812.74
Formula	C42H32N6O12
CAS No.	6184-06-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Giachetti C, Mondino A, Silvestri S, Zanolo G, Bramanti G, Criscuoli M, Subissi A. On the absorption, distribution and excretion of sorbinicate in the rat and the monkey. Arzneimittelforschung. 1982;32(11):1433-6. PubMed PMID: 6891249. 2. Strano A, Novo S, Davì G, Avellone G, Mandalà V. Effects of sorbinicate and nicotinic acid on blood viscosity, red cell deformation and platelet function. Pharmacol Res Commun. 1982 Jul;14(7):639-48. PubMed PMID: 7134249. 3. Subissi A, Murmann W. Correlation between the plasma concentration of free nicotinic acid and some of its pharmacological effects in the fasted rat after an oral dose of sorbinicate and of nicotinic acid. Arzneimittelforschung. 1978;28(7):1143-5. PubMed PMID: 582703. 4. Subissi A, Biagi M, Murmann W. Some aspects of sorbinicate pharmacokinetics. Arzneimittelforschung. 1980;30(8):1278-84. PubMed PMID: 7192142.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sorbinicate 6184-06-1 LG10017 Sorbinicatum LG10,017 LG-10017 LG 10017 inhibitor inhibit

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