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Skf 107457

Catalog No. T34654 CAS 144285-77-8

Synonyms: Skf107457, Skf-107457

Skf 107457 is a hexapeptide substrate analog with the scissile bond being replaced by a hydroxyethylene isostere.

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Skf 107457, CAS 144285-77-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Skf 107457 is a hexapeptide substrate analog with the scissile bond being replaced by a hydroxyethylene isostere.

Synonyms	Skf107457, Skf-107457
Molecular Weight	578.71
Formula	C28H46N6O7
CAS No.	144285-77-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C. The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. J Biol Chem. 1992 Nov 15;267(32):22770-8. PubMed PMID: 1429626. 2. Wood SJ, Wetzel R. A novel method for the incorporation of glycoprotein-derived oligosaccharides into neoglycopeptides. Bioconjug Chem. 1992 Sep-Oct;3(5):391-6. PubMed PMID: 1420438. 3. Verkhivker GM. Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations. Pac Symp Biocomput. 1996:638-52. PubMed PMID: 9390264. 4. Zhao B, Winborne E, Minnich MD, Culp JS, Debouck C, Abdel-Meguid SS. Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors. Biochemistry. 1993 Dec 7;32(48):13054-60. PubMed PMID: 8241159.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Skf 107457 144285-77-8 Skf107457 Skf-107457 inhibitor inhibit

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