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Sivelestat sodium

Catalog No. T21414 CAS 150374-95-1

Synonyms: ONO 5046, LY-544349, Sivelestat sodium salt, ONO-5046, ONO5046, LY544349, LY 544349

Sivelestat, an inhibitor of human neutrophil elastase, is used in the treatment of acute respiratory failure. Preliminary studies show Sivelestat may improve neuropathic pain.

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Sivelestat sodium, CAS 150374-95-1

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 30.00
1 mL * 10 mM (in DMSO)	5 days	$ 77.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Sivelestat, an inhibitor of human neutrophil elastase, is used in the treatment of acute respiratory failure. Preliminary studies show Sivelestat may improve neuropathic pain.

Synonyms	ONO 5046, LY-544349, Sivelestat sodium salt, ONO-5046, ONO5046, LY544349, LY 544349
Molecular Weight	456.44
Formula	C20H21N2NaO7S
CAS No.	150374-95-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Xiao XG, Zu HG, Li QG, Huang P. Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns. Eur Rev Med Pharmacol Sci. 2016 Feb;20(3):528-36. PubMed PMID: 26914130. 2. Wang J, Dai XJ, Zhang YF, Zhong DF, Wu YL, Chen XY. [Simultaneous determination of sivelestat and its metabolite XW-IMP-A in human plasma using HPLC-MS/MS]. Yao Xue Xue Bao. 2015 Oct;50(10):1318-23. Chinese. PubMed PMID: 26837180. 3. Yamada K, Kobayashi H, Bo R, Takahashi T, Hasegawa Y, Nakamura M, Ishige N, Yamaguchi S. Elevation of pivaloylcarnitine by sivelestat sodium in two children. Mol Genet Metab. 2015 Nov;116(3):192-4. doi: 10.1016/j.ymgme.2015.09.009. Epub 2015 Sep 26. PubMed PMID: 26428892. 4. Miyoshi S, Ito R, Katayama H, Dote K, Aibiki M, Hamada H, Okura T, Higaki J. Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients. Drug Des Devel Ther. 2014 Sep 2;8:1211-9. doi: 10.2147/DDDT.S68030. eCollection 2014. PubMed PMID: 25214765; PubMed Central PMCID: PMC4159222.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sivelestat sodium 150374-95-1 ONO 5046 LY-544349 Sivelestat sodium salt ONO-5046 ONO5046 LY544349 LY 544349 inhibitor inhibit

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