Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sipagladenant (Compound I) is an orally active inverse agonist targeting the adenosine receptor A2A [1]. It possesses potential for utilization in research pertaining to frontal lobe dysfunction [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 766.00 | |
50 mg | 6-8 weeks | $ 995.00 | |
100 mg | 6-8 weeks | $ 1,740.00 |
Description | Sipagladenant (Compound I) is an orally active inverse agonist targeting the adenosine receptor A2A [1]. It possesses potential for utilization in research pertaining to frontal lobe dysfunction [2]. |
In vivo | Sipagladenant administered orally at a dosage of 0.3 mg/kg significantly improves cognitive impairment associated with reduced dopamine function in the medial prefrontal cortex, evident through enhanced exploratory behavior towards novel objects (65.03% exploration time) in comparison to familiar ones (34.97%) [2]. Similarly, at a lower dosage of 0.1 mg/kg, Sipagladenant demonstrates an ability to enhance cognitive function, as shown by a notable increase in alternation behavior in ICR mice with cognitive impairment and/or movement disorder [2]. Moreover, this lower dosage also leads to significant improvements in gait parameters, including a larger maximum contact area and gait area of the left hindpaw compared to controls, alongside a tendency for increased contact and gait area in the right forepaw, highlighting its potential in ameliorating mobility-related symptoms [2]. These findings are based on studies conducted in medial prefrontal dopaminergic terminal-lesioned CD(SD) IGS male rats and ICR mice models, indicating Sipagladenant's broad therapeutic potential across different animal models of neurological impairment. |
Molecular Weight | 397.45 |
Formula | C20H19N3O4S |
CAS No. | 858979-50-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Sipagladenant 858979-50-7 inhibitor inhibit