Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 which is a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 977.00 | |
50 mg | 6-8 weeks | $ 1,270.00 | |
100 mg | 6-8 weeks | $ 1,990.00 |
Description | Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 which is a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation [1] [2] [3]. |
In vitro | The impact of Sibrafiban on platelet activation is evaluated through measures of P-selectin expression, fibrinogen binding, and microaggregate formation. Sibrafiban concentration-dependently inhibits both ADP and TRAP-induced fibrinogen binding and microaggregate formation, while having minimal effect on P-selectin expression. Furthermore, a reduction in Sibrafiban's site occupancy does not lead to an increase in platelet activation [3]. |
In vivo | The activity of Ro 44-3888 on both ADP-induced platelet aggregation (17 μmol) and cutaneous bleeding duration was assessed in eight rhesus monkeys administered Sibrafiban at dosages of 0.25 mg/kg/day or 0.5 mg/kg/day through oral administration over eight days. Results demonstrated that Ro 44-3888 exhibits a dose-dependent maximal inhibition of ex vivo platelet aggregation alongside an extension of bleeding time [1]. |
Synonyms | RO-48-3657/001, RO-48-3657, RO 48-3657/001 |
Molecular Weight | 420.46 |
Formula | C20H28N4O6 |
CAS No. | 172927-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Sibrafiban 172927-65-0 RO-48-3657/001 RO-48-3657 RO 48-3657/001 inhibitor inhibit