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Seneciphylline N-oxide

Catalog No. TN2204 CAS 38710-26-8

Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.

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Seneciphylline N-oxide Chemical Structure

Seneciphylline N-oxide, CAS 38710-26-8

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Description	Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.
In vitro	Root cultures of Senecio erucifolius (Asteraceae) efficiently took up and incorporated [14C]putrescine and [14C]arginine into the pyrrolizidine alkaloid (PA) senecionine N-oxide. Pulse-chase experiments covering a growth period of 10 to 19 days revealed the absence of any significant alkaloid turnover[1]
In vivo	Seneciphylline was quickly absorbed into plasma (Tmax , 0.23-0.32 h) and reached the maximum concentration of 0.82-1.75 μg/mL after oral administration. Both seneciphylline and seneciphylline N-oxide were eliminated from plasma quickly. The low system exposure (oral bioavailability, 5.43-10.31%) was related to the extensive metabolism in the liver and microflora.[2]

Molecular Weight	349.38
Formula	C18H23NO6
CAS No.	38710-26-8

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store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Site of synthesis, metabolism and translocation of senecionine N-oxide in cultured roots of Senecio erucifoliusPlant Cell, Tissue and Organ Culture, 1989,18(1):19-31. 2. Long F, et al. LC-MS/MS method for determination of seneciphylline and its metabolite, seneciphylline N-oxide in rat plasma, and its application to a rat pharmacokinetic study. Biomed Chromatogr. 2021 Sep;35(9):e5145.

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Keywords

Seneciphylline N-oxide 38710-26-8 Seneciphylline Noxide Seneciphylline N oxide inhibitor inhibit

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