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Home > Neuroscience > Gamma-secretase > Semagacestat

Semagacestat

Catalog No. T6125    CAS 425386-60-3    Synonyms: LY450139

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).

Pack Size Availability Price/USD Quantity
2 mg In stock 67.00
5 mg In stock 127.00
10 mg In stock 180.00
25 mg In stock 443.00
50 mg In stock 540.00
100 mg Inquiry 918.00
1 mL * 10 mM (in DMSO) In stock 130.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).

Receptor:

Notch; γ secretase(Aβ38); γ secretase(Aβ40); γ secretase(Aβ42);

Chemical Information:
Molecular Weight 361.44
Formula C19H27N3O4
CAS Number 425386-60-3
Solubility

DMSO: 67 mg/mL (185.4 mM)

Ethanol: 39 mg/mL (107.9 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Reference
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