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Seletracetam lithium bromide

Catalog No. T39428 CAS 2024584-38-9

Synonyms: Ucb 44212 lithium bromide

Seletracetam (Ucb 44212) lithium bromide is a SV2A modulator, intended for epilepsy research. It is an analog of Levetiracetam, an antiepileptic agent.

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Seletracetam lithium bromide Chemical Structure

Seletracetam lithium bromide, CAS 2024584-38-9

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Description	Seletracetam (Ucb 44212) lithium bromide is a SV2A modulator, intended for epilepsy research. It is an analog of Levetiracetam, an antiepileptic agent.
In vitro	Seletracetam demonstrates a significantly higher affinity for the LEV-binding site, with a one-log-unit increase (pKi=7.1) compared to Levetiracetam (pKi=6.1). Additionally, in rat cortical neurons in vitro, Seletracetam lithium bromide effectively inhibits both high-voltage-activated calcium currents and the subsequent intracellular calcium increase. At concentrations ranging from 1 to 10 μM, Seletracetam lithium bromide also markedly reduces the amplitude and repetitive firing of population spikes in rat hippocampal slices, an effect induced by a high potassium/low calcium concentration fluid (HKLCF).
In vivo	Seletracetam, administered via intraperitoneal injection as lithium bromide, has demonstrated significant efficacy in mitigating secondary generalized motor seizures in fully corneally-kindled mice, with an effective dose (ED50) of 0.31 mg/kg. In mice prone to audiogenic seizures, Seletracetam offers protection from clonic convulsions with an ED50 of 0.17 mg/kg. Further investigation reveals that doses ranging from 0.0074 mg/kg to 74 mg/kg enhance the generalized seizure threshold current, reduce the duration and severity of after-discharges, and display a considerably stronger effect than Levetiracetam. Studies conducted on female Wistar rats (200-220 g) that were amygdala-kindled showed that pre-seizure threshold determination administration of Seletracetam significantly elevates the generalized seizure threshold across all doses, demonstrating increases of 190% (0.0074 mg/kg), 302% (0.074 mg/kg), 429% (0.74 mg/kg), 433% (7.4 mg/kg), and 679% (74 mg/kg), indicative of its potent anticonvulsant properties.

Synonyms	Ucb 44212 lithium bromide
Molecular Weight	319.07
Formula	C10H14BrF2LiN2O2
CAS No.	2024584-38-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. 2. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10. 3. Matagne A, et al. Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy. Eur J Pharmacol. 2009;614(1-3):30-37.

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Keywords

Seletracetam lithium bromide 2024584-38-9 Seletracetam lithium Bromide Ucb 44212 lithium Bromide Ucb 44212 lithium bromide inhibitor inhibit

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