store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 148.00 | |
10 mg | In stock | $ 215.00 | |
25 mg | In stock | $ 357.00 | |
50 mg | In stock | $ 530.00 | |
100 mg | In stock | $ 766.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 166.00 |
Description | SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration. |
Targets&IC50 | PDGFRβ:10 nM, PDGFR2:140 nM, PDGFR1:2.29 μM |
In vitro | SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM. SU16f pretreatment causes the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA [1]. |
Synonyms | 3-substituted indolin-2-one 16f, SU-16F, SU 16F |
Molecular Weight | 386.44 |
Formula | C24H22N2O3 |
CAS No. | 251356-45-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (64.69 mM)
You can also refer to dose conversion for different animals. More
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SU16f 251356-45-3 Angiogenesis Tyrosine Kinase/Adaptors PDGFR 3-substituted indolin-2-one 16f SU-16F SU 16F inhibitor inhibit