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SP203

Catalog No. T34688 CAS 945933-41-5

Synonyms: SP-203, SP 203

SP203 is a radioligand for brain metabotropic glutamate receptor imaging.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SP203, CAS 945933-41-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SP203 is a radioligand for brain metabotropic glutamate receptor imaging.

Synonyms	SP-203, SP 203
Molecular Weight	260.26
Formula	C13H6F2N2S
CAS No.	945933-41-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lohith TG, Tsujikawa T, Siméon FG, Veronese M, Zoghbi SS, Lyoo CH, Kimura Y, Morse CL, Pike VW, Fujita M, Innis RB. Comparison of two PET radioligands, [(11)C]FPEB and [(11)C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain. J Cereb Blood Flow Metab. 2016 Jan 1:271678X16668891. doi: 10.1177/0271678X16668891. [Epub ahead of print] PubMed PMID: 27629098. 2. Siméon FG, Liow JS, Zhang Y, Hong J, Gladding RL, Zoghbi SS, Innis RB, Pike VW. Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors. Eur J Nucl Med Mol Imaging. 2012 Dec;39(12):1949-58. doi: 10.1007/s00259-012-2205-x. Epub 2012 Aug 11. PubMed PMID: 22885775. 3. Kimura Y, Siméon FG, Zoghbi SS, Zhang Y, Hatazawa J, Pike VW, Innis RB, Fujita M. Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203. Neuroimage. 2012 Feb 1;59(3):2124-30. doi: 10.1016/j.neuroimage.2011.10.028. Epub 2011 Oct 19. PubMed PMID: 22032949; PubMed Central PMCID: PMC3254783. 4. Kimura Y, Siméon FG, Hatazawa J, Mozley PD, Pike VW, Innis RB, Fujita M. Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans. Eur J Nucl Med Mol Imaging. 2010 Oct;37(10):1943-9. doi: 10.1007/s00259-010-1447-8. Epub 2010 Jun 29. PubMed PMID: 20585776; PubMed Central PMCID: PMC3207261.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SP203 945933-41-5 SP-203 SP 203 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.