Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 198.00 | |
1 mg | 35 days | $ 380.00 | |
5 mg | 35 days | $ 1,280.00 |
Description | SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. |
In vitro | It induces NF-κB signaling in cells expressing human TLR2 (EC50= 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. |
In vivo | In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model. |
Molecular Weight | 337.44 |
Formula | C16H23N3O3S |
CAS No. | 903864-87-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF:PBS (pH 7.2) (1:4): 0.20 mg/mL
DMSO: Slightly soluble
DMF: 1 mg/mL
You can also refer to dose conversion for different animals. More
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SMU127 903864-87-9 SMU-127 SMU 127 inhibitor inhibit