Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 73.00 | |
10 mg | In stock | $ 123.00 | |
25 mg | In stock | $ 289.00 | |
50 mg | In stock | $ 538.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 80.00 |
Description | SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. |
In vitro | SB 243213 shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows weak affinity (pKi<6.5) for the cloned human 5-HT1D and D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor[1]. |
In vivo | SB 243213 (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box[1]. SB 243213 (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction[1]. Animal Model: Male Sprague-Dawley experimentally naive rats (220-300 g)[1] |
Molecular Weight | 428.41 |
Formula | C22H19F3N4O2 |
CAS No. | 200940-22-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SB 243213 200940-22-3 SB-243213 SB243213 inhibitor inhibit