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S130

Catalog No. T12819   CAS 1160852-22-1

S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.

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S130 Chemical Structure
S130, CAS 1160852-22-1
Pack Size Availability Price/USD Quantity
1 mg 5 days $ 116.00
5 mg 5 days $ 297.00
50 mg 6-8 weeks $ 1,360.00
100 mg 6-8 weeks $ 1,860.00
1 mL * 10 mM (in DMSO) 5 days $ 318.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
Targets&IC50 ATG4B:3.24 µM
In vitro S130 suppresses autophagy and activates apoptosis by inhibiting ATG4B, leads to enhanced cytotoxicity. S130 (0-25 μM; 48 hours) induces cell death through inhibiting the activity of ATG4B at a dose higher than 6.3 μM. And such cytotoxicity might not cause cell death through necroptosis. Nutrient deprivation enhances S130-induced cytotoxicity. S130 (0-10μM; 24 hours) suppresses approximately 79% of the cleavage of full-length LC3-GST at the 10 μM, while no substrates were processed in ATG4B KO cells. S130 displays obvious inhibitory effects on ATG4B.
In vivo Tumor growth suppressed by S130 (20 mg/kg; i.p.; daily; 3 weeks), S130 shows an efficient in vivo antitumor effect with a sound safety on vital organs.
Molecular Weight 387.47
Formula C24H25N3O2
CAS No. 1160852-22-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (322.61 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Fu Y, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 20:1-17.

Related Products

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LV-320 MIV-247 GLPG2451 Petesicatib Cysteine protease inhibitor-2 ONO-5334 LHVS 2-Aminoethanethiol

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Keywords

S130 1160852-22-1 Proteases/Proteasome Cysteine Protease S-130 S 130 inhibitor inhibit

 

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