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Ropinirole

Catalog No. T60418 CAS 91374-21-9

Ropinirole (SKF 101468) is a selective D2-like family receptor agonist whereas it has no affinity for the D1 receptors. It is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor, which also has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has the potential for the treatment of Parkinson's disease[1] [2].

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Ropinirole, CAS 91374-21-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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Biological Description

Chemical Properties

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Description	Ropinirole (SKF 101468) is a selective D2-like family receptor agonist whereas it has no affinity for the D1 receptors. It is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor, which also has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has the potential for the treatment of Parkinson's disease[1] [2].
In vitro	Ropinirole has 10-20 times higher affinity for D 3 receptors than for D 2 and D 4 receptors. It is weakly active at α2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobu acid receptors or α1 and β-adrenoceptors [1] [2].
In vivo	Ropinirole, administered intraperitoneally at doses ranging from 0.1 to 10 mg/kg, effectively reduces intracranial self-stimulation thresholds and exhibits anxiolytic- and antidepressant-like properties, without impacting motor function or spatial memory [2].

Molecular Weight	260.37
Formula	C16H24N2O
CAS No.	91374-21-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Ropinirole 91374-21-9 inhibitor inhibit

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