Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modulate quorum sensing and control P. aeruginosa infections [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modulate quorum sensing and control P. aeruginosa infections [1]. |
In vitro | RhlR antagonist 1 (compound 30) at 10 μM concentration significantly impedes P. aeruginosa biofilm formation by 74%, concurrently diminishing carbohydrate and protein content by 39% and 72%, respectively. It markedly curtails rhamnolipid synthesis at both 10 and 100 μM. Moreover, a 24-hour exposure to 0-10 μM of RhlR antagonist 1 notably suppresses rhlA gene expression in biofilm cells. Consequently, this compound effectively obstructs the formation of P. aeruginosa biofilms and the production of virulence factors by down-regulating rhlA expression in P. aeruginosa. |
In vivo | Larvae administered with P. aeruginosa began experiencing mortality within the initial incubation phase, resulting in a 70% mortality rate by the conclusion of the 20-day period. Treatment with RhlR antagonist 1 (0-10 μM) significantly enhanced survival, with about 80% of larvae surviving by the period's end. Moreover, larvae inoculated with rhlR mutants of P. aeruginosa exhibited a 90% survival rate after 20 days [1]. |
Molecular Weight | 208.2 |
Formula | C12H10F2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RhlR antagonist 1 inhibitor inhibit