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RU28362

Catalog No. T28623 CAS 74915-64-3

Synonyms: RU-28362, RU 28362

RU28362 is an agonist of glucocorticoid receptor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RU28362, CAS 74915-64-3

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,820.00
50 mg	8-10 weeks	$ 2,380.00
100 mg	8-10 weeks	$ 3,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

RU28362 is an agonist of glucocorticoid receptor.

Synonyms	RU-28362, RU 28362
Molecular Weight	352.47
Formula	C23H28O3
CAS No.	74915-64-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Francis AB, Pace TW, Ginsberg AB, Rubin BA, Spencer RL. Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis. Neuroscience. 2006 Sep 1;141(3):1503-15. Epub 2006 Jun 27. PubMed PMID: 16806720. 2. Ginsberg AB, Frank MG, Francis AB, Rubin BA, O'Connor KA, Spencer RL. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. PubMed PMID: 16420282. 3. Spencer RL, Moday HJ, Miller AH. Maintenance of Basal ACTH Levels by Corticosterone and RU28362, but not Aldosterone: Relationship to Available Type I and Type II Corticosteroid Receptor Levels in Brain and Pituitary. Stress. 1997 Oct;2(1):51-64. PubMed PMID: 9787255. 4. Langley SC, Rickett GW, Hunt A, Kelly FJ, Postle AD, York DA. Effects of the glucocorticoid agonist, RU28362, and the antagonist RU486 on lung phosphatidylcholine and antioxidant enzyme development in the genetically obese Zucker rat. Biochem Pharmacol. 1993 Feb 9;45(3):543-51. PubMed PMID: 8442753.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RU28362 74915-64-3 RU-28362 RU 28362 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.