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RP5063 Hydrochloride

Catalog No. T24736 CAS 1708960-04-6

Synonyms: RP-5063 HCl, RP 5063 HCl, RP 5063 Hydrochloride, RP-5063 Hydrochloride, RP5063 HCl

RP5063 Hydrochloride is a modulator of multimodal serotonin receptors.

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RP5063 Hydrochloride, CAS 1708960-04-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

RP5063 Hydrochloride is a modulator of multimodal serotonin receptors.

Synonyms	RP-5063 HCl, RP 5063 HCl, RP 5063 Hydrochloride, RP-5063 Hydrochloride, RP5063 HCl
Molecular Weight	486.82
Formula	C22H26Cl3N3O3
CAS No.	1708960-04-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bhat L, Hawkinson J, Cantillon M, Reddy DG, Bhat SR, Laurent CE, Bouchard A, Biernat M, Salvail D. Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model. Eur J Pharmacol. 2018 Feb 14. pii: S0014-2999(18)30096-7. doi: 10.1016/j.ejphar.2018.02.017. [Epub ahead of print] PubMed PMID: 29453947. 2. Cantillon M, Bhat L. Response to concerns over Cantillon et al. dopamine serotonin stabilizer RP5063 clinical trial's design, analyses and findings (SCHRES-D-17-00455) by Ahmed S Aboraya, MD, DrPh. Schizophr Res. 2018 Jan 21. pii: S0920-9964(17)30569-8. doi: 10.1016/j.schres.2017.09.010. [Epub ahead of print] PubMed PMID: 29395606. 3. Cantillon M, Ings R, Bhat L. Pharmacokinetics of RP5063 Following Single Doses to Normal Healthy Volunteers and Multiple Doses Over 10 Days to Stable Schizophrenic Patients. Clin Transl Sci. 2017 Nov 8. doi: 10.1111/cts.12518. [Epub ahead of print] PubMed PMID: 29119704. 4. Aboraya A. Concerns about the design, analyses, and findings of the trial of dopamine serotonin stabilizer RP5063 by Cantillon and colleagues. Schizophr Res. 2017 Aug 25. pii: S0920-9964(17)30508-X. doi: 10.1016/j.schres.2017.08.034. [Epub ahead of print] PubMed PMID: 28847613.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RP5063 Hydrochloride 1708960-04-6 RP-5063 HCl RP 5063 HCl RP 5063 Hydrochloride RP-5063 Hydrochloride RP5063 HCl inhibitor inhibit

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