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RG7713

Catalog No. T4141 CAS 920022-47-5

Synonyms: RO 5028442

RG7713 (RO 5028442) has been used in trials studying Autistic Disorder.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RG7713, CAS 920022-47-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 54.00
5 mg	In stock	$ 121.00
10 mg	In stock	$ 211.00
25 mg	In stock	$ 356.00
50 mg	In stock	$ 533.00
100 mg	In stock	$ 769.00
1 mL * 10 mM (in DMSO)	In stock	$ 121.00

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Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RG7713 (RO 5028442) has been used in trials studying Autistic Disorder.
Targets&IC50	V1a receptor (human):1 nM(Ki）, V1a receptor (mouse):39nM(Ki）
In vitro	RO5028442 (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RO5028442 shows high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies[1].

Synonyms	RO 5028442
Molecular Weight	437.96
Formula	C25H28ClN3O2
CAS No.	920022-47-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.38 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library ReFRAME Related Library CNS-Penetrant Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Conopressin S acetate(111317-90-9 free base) Terlipressin Acetate Atosiban Argipressin Conivaptan hydrochloride Dp[Tyr(methyl)2,Arg8]-Vasopressin (D-Arg8)-Inotocin Felypressin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RG7713 920022-47-5 GPCR/G Protein Vasopressin Receptor RG-7713 RO 5028442 Inhibitor RG 7713 RO-5028442 RO5028442 inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.