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RF9 acetate

Catalog No. T16738L

RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RF9 acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 212.00
10 mg	In stock	$ 318.00
25 mg	In stock	$ 573.00
50 mg	In stock	$ 819.00
100 mg	In stock	$ 1,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 283.00

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Purity: 99.35%

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Description	RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
Targets&IC50	NPFF1 (human):58 nM (Ki), NPFF2 (human):75 nM (Ki)
In vitro	In Neuro 2A cells, Pretrement of RF9 acetate (10 μM) completely blocks NPFF induced neurite outgrowth[2].
In vivo	RF9 acetate (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked When RF9 acetate is applied in conjunction with NPFF. RF9 acetate (0.1 mg/kg, s.c. min before 0.3 mg/kg heroin or saline on basal nociceptive threshold) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[2].

Molecular Weight	542.67
Formula	C28H42N6O5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (101.35 mM)

References and Literature

1. Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643. 2. Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Bioactive Compound Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

GW438014A Selvigaltin Pancreatic Polypeptide (human) acetate Neuropeptide SF(mouse,rat) acetate (Leu31,Pro34)-Peptide YY (human) (TFA) AR-M 1896 Acetate JNJ-31020028 M871 acetate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

RF9 acetate GPCR/G Protein Neuroscience Neuropeptide Y Receptor RF9 Acetate RF-9 acetate(876310-60-0 Free base) RF-9 Acetate RF 9 Acetate inhibitor inhibit

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