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Quinaprilat hydrate

Catalog No. T28485 CAS 1435786-09-6

Synonyms: Quinaprilat, CI-928, CI 928, BRN 5653070

Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme inhibitor used in the treatment of congestive heart failure and hypertension.

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Quinaprilat hydrate, CAS 1435786-09-6

Pack Size	Availability	Price/USD	Quantity
10 mg	Inquiry	$ 293.00
25 mg	Inquiry	$ 540.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme inhibitor used in the treatment of congestive heart failure and hypertension.

Synonyms	Quinaprilat, CI-928, CI 928, BRN 5653070
Molecular Weight	428.48
Formula	C23H28N2O6
CAS No.	1435786-09-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Davis JL, Kruger K, LaFevers DH, Barlow BM, Schirmer JM, Breuhaus BA. Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses. Equine Vet J. 2014 Nov;46(6):729-33. doi: 10.1111/evj.12206. Epub 2014 Jan 7. PubMed PMID: 24175935. 2. Kieback AG, Felix SB, Reffelmann T. Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1337-47. doi: 10.1517/17425250903282773. Review. PubMed PMID: 19761414. 3. Sora I, Cristea E, Albu F, Udrescu S, David V, Medvedovici A. LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation. Bioanalysis. 2009 Apr;1(1):71-86. doi: 10.4155/bio.09.5. PubMed PMID: 21083190. 4. van Beusekom HM, Ferrero V, Ribichini F, van der Giessen WJ. Quinaprilat-eluting stents do not attenuate intimal thickening following stenting in porcine coronary arteries. Atherosclerosis. 2009 Jul;205(1):120-5. doi: 10.1016/j.atherosclerosis.2008.11.029. Epub 2008 Dec 6. PubMed PMID: 19135197.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Quinaprilat hydrate 1435786-09-6 Quinaprilat CI-928 BRN-5653070 CI928 CI 928 BRN5653070 Quinaprilat Hydrate BRN 5653070 inhibitor inhibit

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