Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise for research into Alzheimer’s disease (AD) and aging-related disorders[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 916.00 | |
50 mg | 6-8 weeks | $ 1,190.00 | |
100 mg | 6-8 weeks | $ 1,860.00 |
Description | Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise for research into Alzheimer’s disease (AD) and aging-related disorders[1]. |
In vitro | Q134R (1-10 μM) effectively inhibits NFAT signaling without impacting calcineurin function. It achieves partial suppression of NFAT activity in primary rat astrocytes without hindering the calcineurin-mediated dephosphorylation of non-NFAT targets, both in vivo and in vitro[1]. |
In vivo | Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology[1]. |
Synonyms | Q134R |
Molecular Weight | 410.39 |
Formula | C22H17F3N4O |
CAS No. | 2022949-46-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Q134R 2022949-46-6 Q-134R inhibitor inhibit