Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 226.00 | |
50 mg | In stock | $ 382.00 | |
100 mg | In stock | $ 538.00 | |
200 mg | In stock | $ 777.00 | |
500 mg | In stock | $ 1,180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 78.00 |
Description | Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM). |
Targets&IC50 | TRPC3:700 nM |
In vitro | Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner[1]. |
Molecular Weight | 456.63 |
Formula | C16H11Cl3F3N3O3 |
CAS No. | 1160514-60-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (219 mM)
You can also refer to dose conversion for different animals. More
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Pyr3 1160514-60-2 Membrane transporter/Ion channel TRP/TRPV Channel Pyr-3 inhibitor inhibit