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Pumiliotoxin C

Catalog No. T34192 CAS 27766-71-8

Synonyms: Decahydro-5-methyl-2-propylquinoline, 5-Methyl-2-propyldecahydroquinoline

Pumiliotoxins (PTXs), are one of several toxins found in the skin of poison dart frogs. There are three different types of this toxin: A, B and C, of which toxins A and B are more toxic than C. Pumiliotoxins interfere with muscle contraction by affecting calcium channels, causing partial paralysis, difficulty moving, hyperactivity, or death.

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Pumiliotoxin C, CAS 27766-71-8

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Decahydro-5-methyl-2-propylquinoline, 5-Methyl-2-propyldecahydroquinoline
Molecular Weight	195.35
Formula	C13H25N
CAS No.	27766-71-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Qu J, Helmchen G. Applications of Iridium-Catalyzed Asymmetric Allylic Substitution Reactions in Target-Oriented Synthesis. Acc Chem Res. 2017 Oct 17;50(10):2539-2555. doi: 10.1021/acs.accounts.7b00300. Epub 2017 Sep 22. PubMed PMID: 28937739. 2. Tarvin RD, Santos JC, O'Connell LA, Zakon HH, Cannatella DC. Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs. Mol Biol Evol. 2016 Apr;33(4):1068-81. doi: 10.1093/molbev/msv350. Epub 2016 Jan 18. PubMed PMID: 26782998. 3. Suryavanshi PA, Sridharan V, Maiti S, Menéndez JC. Fully diastereoselective synthesis of polysubstituted, functionalized piperidines and decahydroquinolines based on multicomponent reactions catalyzed by cerium(IV) ammonium nitrate. Chemistry. 2014 Jul 7;20(28):8791-9. doi: 10.1002/chem.201402607. Epub 2014 Jun 6. PubMed PMID: 24909665. 4. Dion I, Vincent-Rocan JF, Zhang L, Cebrowski PH, Lebrun ME, Pfeiffer JY, Bédard AC, Beauchemin AM. Studies on difficult intramolecular hydroaminations in the context of four syntheses of alkaloid natural products. J Org Chem. 2013 Dec 20;78(24):12735-49. doi: 10.1021/jo4023149. Epub 2013 Dec 4. PubMed PMID: 24274926.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pumiliotoxin C 27766-71-8 Decahydro-5-methyl-2-propylquinoline 5-Methyl-2-propyldecahydroquinoline inhibitor inhibit

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