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Pseudobufarenogin

Catalog No. TQ0065 CAS 17008-69-4

Synonyms: ψ-Bufarenogin

Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.

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Pseudobufarenogin, CAS 17008-69-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 250.00
10 mg	In stock	$ 368.00
25 mg	In stock	$ 623.00
50 mg	In stock	$ 887.00
1 mL * 10 mM (in DMSO)	In stock	$ 270.00

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Purity: 99.34%

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Description

Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.

In vitro

ψ-Bufarenogin, a novel active compound that we isolated from the extract of toad skin, exhibited potent therapeutic effect in xenografted human hepatoma without notable side effects.?In vitro, ψ-Bufarenogin suppressed HCC cells proliferation through impeding cell cycle progression, and it facilitated cell apoptosis by downregulating Mcl-1 expression.?Moreover, ψ-Bufarenogin decreased the number of hepatoma stem cells through Sox2 depression and exhibited synergistic effect with conventional chemotherapeutics.?Mechanistic study revealed that ψ-Bufarenogin impaired the activation of MEK/ERK pathway, which is essential in the proliferation of hepatoma cells.?ψ-Bufarenogin notably suppressed PI3-K/Akt cascade, which was required in ψ-Bufarenogin-mediated reduction of Mcl-1 and Sox2.?ψ-Bufarenogin inhibited the auto-phosphorylation and activation of epithelial growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-Met), thereafter suppressed their primary downstream cascades Raf/MEK/ERK and PI3-K/Akt signaling.?Taken together, ψ-Bufarenogin suppressed HCC growth via inhibiting, at least partially, receptor tyrosine kinases-regulated signaling, suggesting that ψ-Bufarenogin could be a novel lead compound for anti-HCC drug.

Synonyms	ψ-Bufarenogin
Molecular Weight	416.51
Formula	C24H32O6
CAS No.	17008-69-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (144.05 mM)

References and Literature

1. Ding J, et al. ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling. Oncotarget. 2015 May 10;6(13):11627-39.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Tumor Natural Product Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Natural Product Library NO PAINS Compound Library Natural Product Library for HTS Traditional Chinese Medicine Monomer Library RO5 Drug-like Natural Product Library

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Keywords

Pseudobufarenogin 17008-69-4 Others Inhibitor inhibit psi-Bufarenogin ψ-Bufarenogin inhibitor

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