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Propagermanium

Catalog No. T20641 CAS 12758-40-6

Synonyms: Dipropanoic acid germanium sequioxide, SK-818, Ge 132, Ge132, SK 818, Ge-132

Propagermanium (Ge132), an organometallic compound of germanium, has been used as a therapeutic agent against chronic hepatitis B in Japan.

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Propagermanium, CAS 12758-40-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 192.00
100 mg	In stock	$ 287.00
200 mg	In stock	$ 431.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Propagermanium (Ge132), an organometallic compound of germanium, has been used as a therapeutic agent against chronic hepatitis B in Japan.

Synonyms	Dipropanoic acid germanium sequioxide, SK-818, Ge 132, Ge132, SK 818, Ge-132
Molecular Weight	339.42
Formula	C6H10Ge2O7
CAS No.	12758-40-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Mizuno N, Nishibori E, Oka M, Jomori T, Takata M, Kumasaka T. Structural Basis for Polymer Packing and Solvation Properties of the Organogermanium Crystalline Polymer Propagermanium and Its Derivatives. J Pharm Sci. 2015 Aug;104(8):2482-8. doi: 10.1002/jps.24486. Epub 2015 Jun 2. PubMed PMID: 26037234. 2. Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H. C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice. J Atheroscler Thromb. 2010 Mar 31;17(3):219-28. Epub 2010 Feb 24. PubMed PMID: 20179360. 3. Tsukuda K, Mogi M, Iwanami J, Min LJ, Jing F, Oshima K, Horiuchi M. Irbesartan attenuates ischemic brain damage by inhibition of MCP-1/CCR2 signaling pathway beyond AT₁ receptor blockade. Biochem Biophys Res Commun. 2011 Jun 3;409(2):275-9. doi: 10.1016/j.bbrc.2011.04.142. Epub 2011 May 14. PubMed PMID: 21575596. 4. Tsutsumi Y, Tanaka J, Kanamori H, Musashi M, Minami H, Fukushima A, Yamato H, Ehira N, Kawamura T, Obara S, Ogura N, Asaka M, Imamura M, Masauzi N. Effectiveness of propagermanium treatment in multiple myeloma patients. Eur J Haematol. 2004 Dec;73(6):397-401. PubMed PMID: 15522060.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library NO PAINS Compound Library ReFRAME Related Library Approved Drug Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Propagermanium 12758-40-6 Others Dipropanoic acid germanium sequioxide SK-818 SK818 Ge 132 Ge132 SK 818 Ge-132 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.