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Preussin

Catalog No. T34131 CAS 119463-16-0

Synonyms: L 657,398, L657,398, L-657,398

Preussin is a new hydroxypyrrolidine alkaloid from Aspergillus ochraceus.

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Preussin, CAS 119463-16-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Preussin is a new hydroxypyrrolidine alkaloid from Aspergillus ochraceus.

Synonyms	L 657,398, L657,398, L-657,398
Molecular Weight	317.51
Formula	C21H35NO
CAS No.	119463-16-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Buttachon S, Ramos AA, Inácio Â, Dethoup T, Gales L, Lee M, Costa PM, Silva AMS, Sekeroglu N, Rocha E, Pinto MMM, Pereira JA, Kijjoa A. Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062. Mar Drugs. 2018 Apr 6;16(4). pii: E119. doi: 10.3390/md16040119. PubMed PMID: 29642369; PubMed Central PMCID: PMC5923406. 2. Mao H, Jeong H, Yang J, Ha HJ, Yang JW. Preparation of Chiral Contiguous Epoxyaziridines and Their Regioselective Ring-Opening for Drug Syntheses. Chemistry. 2018 Feb 16;24(10):2370-2374. doi: 10.1002/chem.201706161. Epub 2018 Jan 25. PubMed PMID: 29314353. 3. Rong HJ, Yao JJ, Li JK, Qu J. Molecular Iodine-Mediated α-C-H Oxidation of Pyrrolidines to N,O-Acetals: Synthesis of (±)-Preussin by Late-Stage 2,5-Difunctionalizations of Pyrrolidine. J Org Chem. 2017 Jun 2;82(11):5557-5565. doi: 10.1021/acs.joc.7b00361. Epub 2017 May 18. PubMed PMID: 28497692. 4. Si CM, Shao LP, Mao ZY, Zhou W, Wei BG. An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin. Org Biomol Chem. 2017 Jan 18;15(3):649-661. doi: 10.1039/c6ob02523d. PubMed PMID: 27973631.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Preussin 119463-16-0 L 657,398 L657,398 L-657,398 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.