Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Poricoic acid G shows inhibition of tumor-promoting effects and cytotoxic activity.
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5 mg | Inquiry | $ 630.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 650.00 |
Description | Poricoic acid G shows inhibition of tumor-promoting effects and cytotoxic activity. |
In vitro | The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; Poricoic acid G) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid H) on the basis of spectroscopic methods. METHODS AND RESULTS: These two, and eight other known compounds isolated from the sclerotium, poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested. |
Molecular Weight | 486.68 |
Formula | C30H46O5 |
CAS No. | 415724-84-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Poricoic acid G 415724-84-4 inhibitor inhibit