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Physalin H

Catalog No. TN4778 CAS 70241-09-7

Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.

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Physalin H, CAS 70241-09-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	562.99
Formula	C28H31ClO10
CAS No.	70241-09-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Related Products

Related compounds with same targets

Physalin H Moringin Germacrone 4,5-epoxide Ingenol mebutate BMS-378806 YYA-021 Anti-mouse CD4-InVivo

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Physalin H 70241-09-7 免疫与炎症微生物学自噬 gp120/CD4 Autophagy Antifection Inhibitor inhibitor inhibit

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