Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
Description | Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. |
Targets&IC50 | ECE:3.5μM, ACE:78 μM, NEP:0.034μM |
In vitro | Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. [1] Phosphoramidon reduces tumor cell invasion in CC531 cells. [2] |
In vivo | In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. [2] Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD). [3] |
Synonyms | Phosphoramidon Disodium Salt, 磷酰胺二钠 |
Molecular Weight | 587.473 |
Formula | C23H32N3Na2O10P |
CAS No. | 164204-38-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 169.9 mM
DMSO: 169.9 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Phosphoramidon Disodium 164204-38-0 代谢 内分泌与激素 其他 Neprilysin Others RAAS Inhibitor NEP CD10 Angiotensin-converting Enzyme (ACE) Neutral endopeptidase Cluster of differentiation 10 Phosphoramidon Disodium Salt inhibit inhibitor