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Phosphoramidon Disodium

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Phosphoramidon Disodium

Catalog No. T6627Cas No. 164204-38-0

Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.

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Product Introduction

Bioactivity

Description	Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
In vitro	Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. [1] Phosphoramidon reduces tumor cell invasion in CC531 cells. [2]
In vivo	In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. [2] Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD). [3]
Alias	Phosphoramidon Disodium Salt

Chemical Properties

Molecular Weight	588.48
Formula	C23H34N3Na2O10P
Cas No.	164204-38-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 169.9 mM

DMSO: 169.9 mM

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6993 mL	8.4965 mL	16.9929 mL	84.9647 mL
5 mM	0.3399 mL	1.6993 mL	3.3986 mL	16.9929 mL
10 mM	0.1699 mL	0.8496 mL	1.6993 mL	8.4965 mL
20 mM	0.0850 mL	0.4248 mL	0.8496 mL	4.2482 mL
50 mM	0.0340 mL	0.1699 mL	0.3399 mL	1.6993 mL
100 mM	0.0170 mL	0.0850 mL	0.1699 mL	0.8496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc