Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.) |
In vivo | PKM2 activator 3, also known as compound 66, exhibits favorable pharmacokinetic properties, including efficient Caco-2 permeability and a low efflux ratio of 0.84. It demonstrates robust microsomal stability, with a half-life of 277.2 minutes in human liver microsomes and 117.5 minutes in mouse liver microsomes [1]. |
Molecular Weight | 372.77 |
Formula | C15H11ClF2N2O3S |
CAS No. | 1346113-84-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PKM2 activator 3 1346113-84-5 inhibitor inhibit