Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lufotrelvir (PF-07304814) is a phosphate prodrug of PF-00835231 which acts as a potent 3CL pro protease ( M pro ) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CL pro activity with a K i of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle [1].
Pack Size | Availability | Price/USD | Quantity |
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1 mg | In stock | $ 129.00 | |
5 mg | In stock | Inquiry |
Description | Lufotrelvir (PF-07304814) is a phosphate prodrug of PF-00835231 which acts as a potent 3CL pro protease ( M pro ) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CL pro activity with a K i of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle [1]. |
In vivo | Administered intravenously, Lufotrelvir undergoes cleavage into PF-00835231, demonstrating its antiviral efficacy. It maintains a positive cardiovascular safety profile [1]. When given to rats, dogs, and monkeys, Lufotrelvir shows substantial systemic clearance and brief half-life, converting into 68%, 81%, and 76% PF-00835231 in these species, respectively, compared to the systemic exposure from directly intravenous administration of PF00835231 [1]. |
Synonyms | Lufotrelvir |
Molecular Weight | 552.51 |
Formula | C24H33N4O9P |
CAS No. | 2468015-78-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PF-07304814 2468015-78-1 Lufotrelvir PF 07304814 PF07304814 inhibitor inhibit