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PA 21

Catalog No. T33856 CAS 125200-63-7

Synonyms: PA21

PA 21 is an iron-based noncalcium phosphate binder that prevents vascular calcification in chronic renal failure rats.

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PA 21, CAS 125200-63-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

PA 21 is an iron-based noncalcium phosphate binder that prevents vascular calcification in chronic renal failure rats.

Synonyms	PA21
Molecular Weight	270.218
Formula	C9H19O7P
CAS No.	125200-63-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yaguchi A, Tatemichi S, Takeda H, Kobayashi M. PA21, a novel phosphate binder, improves renal osteodystrophy in rats with chronic renal failure. PLoS One. 2017 Jul 13;12(7):e0180430. doi: 10.1371/journal.pone.0180430. eCollection 2017. PubMed PMID: 28704404; PubMed Central PMCID: PMC5509238. 2. Yaguchi A, Yonekubo S, Maruyama I, Tatemichi S, Maruyama K, Kobayashi M. Comparison of Phosphate Binding Capacities of PA21, A Novel Phosphate Binder, with those of other Phosphate Binders in vitro and in vivo. Drug Res (Stuttg). 2016 May;66(5):262-9. doi: 10.1055/s-0035-1569328. Epub 2016 Jan 13. PubMed PMID: 26761712. 3. Koiwa F, Terao A. Dose-response efficacy and safety of PA21 in Japanese hemodialysis patients with hyperphosphatemia: a randomized, placebo-controlled, double-blind, Phase II study. Clin Exp Nephrol. 2017 Jun;21(3):513-522. doi: 10.1007/s10157-016-1299-z. Epub 2016 Jul 7. Erratum in: Clin Exp Nephrol. 2017 Jun;21(3):523. PubMed PMID: 27389681; PubMed Central PMCID: PMC5486467. 4. Xie D, Ye N, Li M. A systematic review on the efficacy and safety of PA21 versus sevelamer in dialysis patients. Int Urol Nephrol. 2018 May;50(5):905-909. doi: 10.1007/s11255-017-1774-9. Epub 2018 Jan 2. Review. PubMed PMID: 29294216.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PA 21 125200-63-7 PA21 PA-21 inhibitor inhibit

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