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P8RI

Catalog No. T39615 CAS 2147724-76-1

Synonyms: D-P8RI

P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties.

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P8RI, CAS 2147724-76-1

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Description	P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties.
In vitro	P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1].
In vivo	P8RI, administered at a dosage of 2.5 mg/kg through subcutaneous injections daily from days 7 to 28 following acute aortic dissection and intramural hematoma (ADIM) occurrence, significantly mitigates aneurysmal transformation. This effect is achieved by hastening the resolution of intramural hematomas, fostering collagen production in dissected aortas, and enhancing M2 macrophage enrichment at the injury site in vivo. The efficacy of this treatment was evaluated using an Apo E -/- male mouse model, 28-week-old, with implanted Ang II-releasing pumps—a model designed to simulate experimental acute aortic dissection and intramural hematoma (ADIM). This regimen resulted in a marked reduction of aneurysmal transformation.

Synonyms	D-P8RI
Molecular Weight	1016.259
Formula	C51H77N13O9
CAS No.	2147724-76-1

Storage

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42(18):1760-1769. 2. Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53(2):746-749. 3. Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72(1):45-57.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

P8RI 2147724-76-1 D-P8RI P-8RI inhibitor inhibit

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