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Oxilorphan

Catalog No. T25910 CAS 42281-59-4

Synonyms: Oxilorfano, Oxilorphane, Bristol laboratories BC 2605, levo-BC-2605

Oxilorphan acts as a μ-opioid receptor (MOR) antagonist but a κ-opioid receptor (KOR) partial agonist and has similar effects to naloxone and around the same potency as a MOR antagonist. Oxilorphan has some weak partial agonist actions at the MOR and can produce hallucinogenic/dissociative effects at sufficient doses, indicative of KOR activation. The KOR agonist effects of oxilorphan are associated with dysphoria, which combined with its hallucinogenic effects, serve to limit its clinical usefulness.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Oxilorphan, CAS 42281-59-4

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,970.00
50 mg	8-10 weeks	$ 2,580.00
100 mg	8-10 weeks	$ 3,400.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Oxilorfano, Oxilorphane, Bristol laboratories BC 2605, levo-BC-2605
Molecular Weight	313.43
Formula	C20H27NO2
CAS No.	42281-59-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Leander JD. Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a kappa-opioid receptor. Eur J Pharmacol. 1983 Jan 21;86(3-4):467-70. PubMed PMID: 6131829. 2. Tennant FS Jr, Tate JA, Ruckel E. Clinical trial in post-addicts with oxilorphan (levo-BC-2605): a new narcotic antagonist. Drug Alcohol Depend. 1976 Jun;1(5):329-37. PubMed PMID: 13984. 3. Sellers EM, Thakur R. Partial agonist properties and toxicity of oral oxilorphan. J Clin Pharmacol. 1976 Apr;16(4):183-7. PubMed PMID: 4472. 4. Pircio AW, Gylys JA. Oxilorphan (l-N-cyclopropylmethyl-3,14-dihydroxymorphinan): a new synthetic narcotic antagonist. J Pharmacol Exp Ther. 1975 Apr;193(1):23-34. PubMed PMID: 237112.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oxilorphan 42281-59-4 Oxilorfano levo-BC2605 Bristol laboratories BC2605 Oxilorphane levo-BC 2605 Bristol laboratories BC-2605 Bristol laboratories BC 2605 levo-BC-2605 inhibitor inhibit

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