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Otenabant

Catalog No. T3530   CAS 686344-29-6
Synonyms: CP-945598

Otenabant (CP-945598) has been investigated for the treatment of Obesity.

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Otenabant Chemical Structure
Otenabant, CAS 686344-29-6
Pack Size Availability Price/USD Quantity
2 mg In stock $ 41.00
5 mg In stock $ 67.00
10 mg In stock $ 96.00
25 mg In stock $ 183.00
50 mg In stock $ 327.00
100 mg In stock $ 488.00
1 mL * 10 mM (in DMSO) In stock $ 75.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Otenabant (CP-945598) has been investigated for the treatment of Obesity.
Targets&IC50 cannabinoid:0.7 nM(Ki)
In vitro Otenabant HCl has a low Ki affinity for human CB2 receptors of 7.6 μM[1]. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration[2].
In vivo Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient which suggests a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle-adjusted weight loss in a 10-day weight loss study in diet-induced obese mice[1]. Otenabant HCl reverses four cannabinoid agonist-mediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation[2].
Synonyms CP-945598
Molecular Weight 510.42
Formula C25H25Cl2N7O
CAS No. 686344-29-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (19.59 mM)

TargetMolReferences and Literature

1. John R. Hadcock, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications, 2010; 394;366-371. 2. Griffith DA, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009 ;5

TargetMolCitations

1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15. 2. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library GPCR Compound Library Drug Repurposing Compound Library Bioactive Compound Library Clinical Compound Library NO PAINS Compound Library ReFRAME Related Library Bioactive Compounds Library Max Inhibitor Library

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Tetrahydrocannabivarin CB1 agonist 1 AZD1940 CB2R/FAAH modulator-2 OMDM-5 Bay 59-3074 (±)-Cannabichromene AEF0117

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Keywords

Otenabant 686344-29-6 GPCR/G Protein Cannabinoid Receptor CP945598 inhibit CP-945598 Inhibitor CP 945598 inhibitor

 

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