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Osilodrostat phosphate

Catalog No. T28272 CAS 1315449-72-9

Synonyms: LCI699 phosphate, LCI 699 phosphate, LCI-699 phosphate

Osilodrostat phosphate is a potent oral 11β-hydroxylase inhibitor.

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Osilodrostat phosphate Chemical Structure

Osilodrostat phosphate, CAS 1315449-72-9

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2 mg	5 days	$ 52.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Osilodrostat phosphate is a potent oral 11β-hydroxylase inhibitor.

Synonyms	LCI699 phosphate, LCI 699 phosphate, LCI-699 phosphate
Molecular Weight	325.23
Formula	C13H13FN3O4P
CAS No.	1315449-72-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cuevas-Ramos D, Lim DST, Fleseriu M. Update on medical treatment for Cushing's disease. Clin Diabetes Endocrinol. 2016 Sep 13;2:16. doi: 10.1186/s40842-016-0033-9. eCollection 2016. Review. PubMed PMID: 28702250; PubMed Central PMCID: PMC5471955. 2. Armani S, Ting L, Sauter N, Darstein C, Tripathi AP, Wang L, Zhu B, Gu H, Chun DY, Einolf HJ, Kulkarni S. Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults. Clin Drug Investig. 2017 May;37(5):465-472. doi: 10.1007/s40261-017-0497-0. PubMed PMID: 28155129; PubMed Central PMCID: PMC5394143. 3. Fleseriu M, Castinetti F. Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies. Pituitary. 2016 Dec;19(6):643-653. Review. PubMed PMID: 27600150; PubMed Central PMCID: PMC5080363. 4. Fleseriu M, Pivonello R, Young J, Hamrahian AH, Molitch ME, Shimizu C, Tanaka T, Shimatsu A, White T, Hilliard A, Tian C, Sauter N, Biller BM, Bertagna X. Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease. Pituitary. 2016 Apr;19(2):138-48. doi: 10.1007/s11102-015-0692-z. PubMed PMID: 26542280; PubMed Central PMCID: PMC4799251.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Osilodrostat phosphate 1315449-72-9 Osilodrostat Phosphate LCI699 phosphate LCI 699 phosphate LCI-699 phosphate LCI699 Phosphate LCI 699 Phosphate LCI-699 Phosphate inhibitor inhibit

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