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Ono 3403

Catalog No. T28241 CAS 181586-07-2

Synonyms: Ono3403, Ono-3403

Ono 3403 is a synthetic serine protease inhibitor. Ono 3403 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production. ONO-3403 also has an antitumor effect on malignant tumors.

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Ono 3403, CAS 181586-07-2

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Ono3403, Ono-3403
Molecular Weight	545.6
Formula	C26H31N3O8S
CAS No.	181586-07-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011 Feb;17(1):97-105. doi: 10.1177/1753425909353641. Epub 2009 Dec 18. PubMed PMID: 20023007. 2. Ohkoshi M, Okuda S. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002 Mar-Apr;22(2A):821-3. PubMed PMID: 12014657. 3. Hiwasa T, Kondo K, Nakagawara A, Ohkoshi M. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998 Apr 24;126(2):221-5. PubMed PMID: 9585070. 4. Ohkoshi M, Denda T, Hiwasa T. Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncol Rep. 1997 May-Jun;4(3):521-3. PubMed PMID: 21590090.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ono 3403 181586-07-2 Ono3403 Ono-3403 inhibitor inhibit

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