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Onapristone

Catalog No. T28237 CAS 96346-61-1

Synonyms: IVV-1001, ZK 98299, IVV 1001, ZK98299, ZK-98299, IVV1001

Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding.

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Onapristone, CAS 96346-61-1

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding.

Synonyms	IVV-1001, ZK 98299, IVV 1001, ZK98299, ZK-98299, IVV1001
Molecular Weight	449.62
Formula	C29H39NO3
CAS No.	96346-61-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rezai K, Chassard D, Denot C, Proniuk S, Zukiwski A, Gilles E, Ramos HL, Patat A, Bexon A, Lokiec F. A single-dose PK study of onapristone including the effect of food on absorption. Cancer Chemother Pharmacol. 2015 Jul;76(1):171-7. doi: 10.1007/s00280-015-2754-3. Epub 2015 May 26. PubMed PMID: 26006702. 2. Rekawiecki R, Kowalik MK, Kotwica J. Onapristone (ZK299) and mifepristone (RU486) regulate the messenger RNA and protein expression levels of the progesterone receptor isoforms A and B in the bovine endometrium. Theriogenology. 2015 Aug;84(3):348-57. doi: 10.1016/j.theriogenology.2015.03.024. Epub 2015 Apr 1. PubMed PMID: 25976976. 3. Guil-Luna S, Hellmén E, Sánchez-Céspedes R, Millán Y, Martín de las Mulas J. The antiprogestins mifepristone and onapristone reduce cell proliferation in the canine mammary carcinoma cell line CMT-U27. Histol Histopathol. 2014 Jul;29(7):949-55. doi: 10.14670/HH-29.949. Epub 2014 Feb 6. PubMed PMID: 24500783. 4. Mann GE, Wathes DC, Robinson RS. The progesterone receptor antagonist, onapristone has differential effects on the timing and control of the luteolytic mechanism depending on timing of administration in sheep. Mol Cell Endocrinol. 2013 Aug 25;376(1-2):1-11. doi: 10.1016/j.mce.2013.06.001. Epub 2013 Jun 7. PubMed PMID: 23748180.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Onapristone 96346-61-1 IVV-1001 ZK 98299 IVV 1001 ZK98299 ZK-98299 IVV1001 inhibitor inhibit

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