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OTX008

Catalog No. T16413 CAS 286936-40-1

Synonyms: Calixarene 0118, PTX008

OTX008 (PTX008) is a selective galectin-1 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

OTX008, CAS 286936-40-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 237.00
25 mg	In stock	$ 488.00
50 mg	In stock	$ 698.00
100 mg	In stock	$ 968.00
500 mg	In stock	$ 1,930.00
1 mL * 10 mM (in DMSO)	In stock	$ 263.00

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Purity: 98.77%

Purity: 98.55%

Purity: 96.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	OTX008 (PTX008) is a selective galectin-1 inhibitor.
In vitro	OTX008 inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways in SQ20B and A2780-1A9 cells and induces G2/M cell cycle arrest through CDK1. OTX008 increases the anti-proliferative effects of Semaphorin-3A (Sema3A) in SQ20B cells and reverses invasion induced by exogenous Gal1. Growth inhibitory concentrations (GI50) of OTX008 range from 3 to 500 μM in a large panel of human solid tumor cell lines. A significant correlation between OTX008 GI50 values and Gal1 mRNA (LGALS1) and protein expression levels in the panel of cancer cells is observed. OTX008 affects endothelial cell proliferation, motility, invasiveness, and cord formation. Tumor cell proliferation is also inhibited, with differences in sensitivity among cell lines (IC50 from 1 to 190 μM)[1][2].
In vivo	OTX008 treatment is associated with the down-regulation of Gal1 and Ki67 in treated tumors, as well as decreased microvessel density and VEGFR2 expression. OTX008 inhibits the growth of A2780-1A9 xenografts. Combination studies display OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first[1].

Synonyms	Calixarene 0118, PTX008
Molecular Weight	937.18
Formula	C52H72N8O8
CAS No.	286936-40-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (10.67 mM), Sonication is recommended.

Ethanol: 33.33 mg/mL (35.56 mM)

References and Literature

1. Astorgues-Xerri L, et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur J Cancer. 2014 Sep;50(14):2463-77. 2. Zucchetti M, et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Inhibitor Library NO PAINS Compound Library Anti-Cancer Compound Library ReFRAME Related Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

G3-C12 acetate(848301-94-0 free base) Galectin-3 antagonist 2 GB1107 Galectin-3/galectin-8-IN-2 TD139 Galectin-3/galectin-8-IN-1 Thiodigalactoside DB21, Galectin-1 Antagonist

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OTX008 286936-40-1 Immunology/Inflammation Galectin OTX 008 OTX-008 Calixarene 0118 PTX-008 PTX008 Calixarene0118 inhibit Calixarene-0118 PTX 008 Inhibitor inhibitor

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