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OSI-7904L free acid

Catalog No. T24572 CAS 139987-54-5

Synonyms: OSI 7904, OSI-7904L, OSI7904, OSI 7904L, OSI7904L, OSI-7904

OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.

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OSI-7904L free acid, CAS 139987-54-5

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,420.00
50 mg	10-14 weeks	$ 3,180.00
100 mg	10-14 weeks	$ 4,300.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.

Synonyms	OSI 7904, OSI-7904L, OSI7904, OSI 7904L, OSI7904L, OSI-7904
Molecular Weight	500.5
Formula	C27H24N4O6
CAS No.	139987-54-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Smith GK, Amyx H, Boytos CM, Duch DS, Ferone R, Wilson HR. Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid. Cancer Res. 1995 Dec 15;55(24):6117-25. PubMed PMID: 8521402. 2. Hanlon MH, Ferone R. In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase. Cancer Res. 1996 Jul 15;56(14):3301-6. PubMed PMID: 8764125. 3. Wilson RH. Novel therapeutic developments other than EGFR and VEGF inhibition in colorectal cancer. Oncologist. 2006 Oct;11(9):1018-24. Review. PubMed PMID: 17030644. 4. Li WW, Tong WP, Bertino JR. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate. Clin Cancer Res. 1995 Jun;1(6):631-6. PubMed PMID: 9816025.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OSI-7904L free acid 139987-54-5 OSI 7904 OSI 7904L free acid OSI-7904L OSI7904 OSI7904L free acid OSI 7904L OSI7904L OSI-7904 inhibitor inhibit

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