Powder: -20°C for 3 years | In solvent: -80°C for 2 years
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 88.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 328.00 | |
50 mg | In stock | $ 571.00 | |
100 mg | In stock | $ 819.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM). |
Targets&IC50 | LPA1:0.19-0.13 μM (IC50) |
In vivo | The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1]. |
Molecular Weight | 461.55 |
Formula | C28H31NO5 |
CAS No. | 638132-34-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 100 mg/mL (216.66 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ONO-7300243 638132-34-0 GPCR/G Protein LPL Receptor LPA Receptor ONO7300243 inhibit Inhibitor ONO 7300243 Lysophospholipid Receptor inhibitor