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ONO-7300243

Catalog No. T7393   CAS 638132-34-0

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).

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ONO-7300243 Chemical Structure
ONO-7300243, CAS 638132-34-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 38.00
2 mg In stock $ 54.00
5 mg In stock $ 88.00
10 mg In stock $ 147.00
25 mg In stock $ 328.00
50 mg In stock $ 571.00
100 mg In stock $ 819.00
1 mL * 10 mM (in DMSO) In stock $ 90.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
Targets&IC50 LPA1:0.19-0.13 μM (IC50)
In vivo The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1].
Molecular Weight 461.55
Formula C28H31NO5
CAS No. 638132-34-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (216.66 mM)

TargetMolReferences and Literature

1. Terakado M , Suzuki H , Hashimura K , et al. Discovery of ONO-7300243 from a novel class of Lysophosphatidic Acid Receptor 1 antagonists: From hit to lead.[J]. ACS Medicinal Chemistry Letters, 2016:acsmedchemlett.6b00225. 2. Terakado M , Suzuki H , Hashimura K , et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia[J]. ACS Medicinal Chemistry Letters, 2017:acsmedchemlett.7b00383.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max GPCR Compound Library Anti-Fibrosis Compound Library Inhibitor Library NO PAINS Compound Library Bioactive Compound Library

Related Products

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BMS-986278 DBIBB TAK-615 AM095 Ki16425 AM966 Tetradecyl Phosphonate ASP6432

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Keywords

ONO-7300243 638132-34-0 GPCR/G Protein LPL Receptor LPA Receptor inhibit Inhibitor ONO 7300243 ONO7300243 Lysophospholipid Receptor inhibitor

 

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