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ONO-7300243

Catalog No. T7393 CAS 638132-34-0

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).

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ONO-7300243, CAS 638132-34-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 88.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 571.00
100 mg	In stock	$ 819.00
1 mL * 10 mM (in DMSO)	In stock	$ 90.00

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Purity: 98%

Biological Description

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Description	ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
Targets&IC50	LPA1:0.19-0.13 μM (IC50)
In vivo	The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1].

Molecular Weight	461.55
Formula	C28H31NO5
CAS No.	638132-34-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (216.66 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Terakado M , Suzuki H , Hashimura K , et al. Discovery of ONO-7300243 from a novel class of Lysophosphatidic Acid Receptor 1 antagonists: From hit to lead.[J]. ACS Medicinal Chemistry Letters, 2016:acsmedchemlett.6b00225. 2. Terakado M , Suzuki H , Hashimura K , et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia[J]. ACS Medicinal Chemistry Letters, 2017:acsmedchemlett.7b00383.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-Fibrosis Compound Library GPCR Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Keywords

ONO-7300243 638132-34-0 GPCR/G Protein LPL Receptor LPA Receptor ONO7300243 inhibit Inhibitor ONO 7300243 Lysophospholipid Receptor inhibitor

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