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ONO-7300243

Catalog No. T7393 CAS 638132-34-0

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).

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ONO-7300243, CAS 638132-34-0

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Purity: 98%

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Description	ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
Targets&IC50	LPA1:0.19-0.13 μM (IC50)
In vivo	The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1].

Molecular Weight	461.558
Formula	C28H31NO5
CAS No.	638132-34-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (216.66 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Terakado M , Suzuki H , Hashimura K , et al. Discovery of ONO-7300243 from a novel class of Lysophosphatidic Acid Receptor 1 antagonists: From hit to lead.[J]. ACS Medicinal Chemistry Letters, 2016:acsmedchemlett.6b00225. 2. Terakado M , Suzuki H , Hashimura K , et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia[J]. ACS Medicinal Chemistry Letters, 2017:acsmedchemlett.7b00383.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Neuronal Signaling Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

TAK-615 Tetradecyl Phosphonate ONO-7300243 Ki16198 TC LPA5 4 H2L5186303 GRI977143 DBIBB

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Keywords

ONO-7300243 638132-34-0 G蛋白偶联受体 LPA Receptor LPL Receptor ONO7300243 inhibit Inhibitor ONO 7300243 Lysophospholipid Receptor inhibitor

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