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OAC2

Catalog No. T2019   CAS 6019-39-2

OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts; an analog of OAC1.

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OAC2 Chemical Structure
OAC2, CAS 6019-39-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 63.00
25 mg In stock $ 128.00
50 mg In stock $ 253.00
100 mg In stock $ 445.00
1 mL * 10 mM (in DMSO) In stock $ 57.00
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Purity: 99.76%
Purity: 99.58%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts; an analog of OAC1.
In vitro Octamer-binding transcription factor 4 (Oct4) is vital for cellular pluripotency initiation and maintenance, playing indispensable roles in the early differentiation stages. It uniquely cannot be replaced by any family members in inducing pluripotency[1]. Essential for embryonic stem cell (ESC) pluripotency and critical in reprogramming, Oct4, alongside Sox2, Klf4, and c-Myc, benefits from the structural analog OAC2—a counterpart of OAC1—that equally activates Oct4 and Nanog reporters. OAC1, along with its analogs OAC2 and OAC3, significantly boosts reprogramming efficiency by four times to as much as 2.75%, and hastens iPSC colony emergence by 3 to 4 days[2].
Cell Research The Oct4-luc or Nanog-luc cells are treated with compound OAC1 or its structural analogs OAC2, OAC3 at 1 μM concentration or at indicated concentrations. Other compounds used include 2 μM BIO, 2 μM BIX, 2 μM 5'-azacytidine, 25 μg/mL Vitamin C, 10 nM Am580, 5 μM tranylcypromine, and 0.5 mM valporic acid. Luciferase reporter assays are performed 24 h after compound treatment or at indicated time points. For Topflash reporter assays, 0.2 μg β-catenin–responsive Topflash reporter gene plasmid is introduced into CV1 cells using trasfection. Compounds are added 6 h after transfection. Luciferase activity is measured 48 h after compound treatment using the Glo Luciferase Assay System[2].
Molecular Weight 236.27
Formula C15H12N2O
CAS No. 6019-39-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23.6 mg/mL(100 mM)

TargetMolReferences and Literature

1. Okuyama T, et al. Structural and mechanistic insights into nuclear transport and delivery of the critical pluripotency factor Oct4 to DNA. J Biomol Struct Dyn. 2017 Feb 6:1-50 2. Li W, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Anti-Aging Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Cancer Compound Library Ion Channel Inhibitor Library Stem Cell Differentiation Compound Library Bioactive Compounds Library Max

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3-O-Methylgallic acid Oct3/4-inducer-1 OAC1 Jatrorrhizine chloride O4I1 O4I2 Retrorsine

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Keywords

OAC2 6019-39-2 Membrane transporter/Ion channel OCT Slc22a3 Oct3/4 inhibit POU5F1 OAC 2 OAC-2 Inhibitor inhibitor

 

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